Initial Launch · Limited Supply   ·  Formulated by Sayer Ji, Founder of GreenMedInfo™
MethylateBLUE Product
MethylateBLUE 1 Bottle Your Mitochondrial Stack Backed by Research Six products in three capsules Formulated by Sayer Ji
MethylateBLUE 1 Bottle Your Mitochondrial Stack Backed by Research Six products in three capsules Formulated by Sayer Ji

MethylateBLUE™

Stimulant-Free Energy & Calm Focus.
Built for Longevity.†
The non-toxic, stimulant-free alternative to methylene blue, nicotine, and energy drinks. A full mitochondrial stack in three capsules, built for biohackers, athletes, and adults 30+ looking to supercharge energy levels without the trade-off.† Phycocyanin and chlorophyll from organic spirulina, the four methylated B vitamins, fermented nicotinamide, and Peptide-Powered Minerals™.
✓Blue phycocyanin from organic spirulina
✓Chlorophyll from organic spirulina (clean electron flow)
✓Four methylated B vitamins: B2, B6, folate, cyanide-free B12
✓Fermented nicotinamide (NAD+ precursor)
✓Peptide-Powered Minerals™ bound to spirulina peptides
✓90 capsules · 30 servings · 3 caps/day

Supplement Facts

Serving Size: 3 Capsules
Servings Per Container: 30
Amount Per Serving% Daily Value
Riboflavin (as R-Boltavin 5'-Phosphate) 1.95 mg 150%
Niacin (as Nicotinamide**) 44 mg 275%
Vitamin B6 (as Pyridoxal 5'-Phosphate) 2.55 mg 150%
Folate (as Calcium L-5-methyltetrahydrofolate) 400 mcg DFE 100%
Vitamin B12 (as Methylcobalamin) 12 mcg 500%
Iron* 9 mg 50%
Iodine* 75 mcg 50%
Magnesium* 110 mg 26%
Zinc* 10 mg 91%
Selenium* 55 mcg 100%
Copper* 0.9 mg 100%
Manganese* 2.3 mg 100%
Chromium* 35 mcg 100%
Molybdenum* 45 mcg 100%
Organic Blue Spirulina Extract 500 mg +

+ Daily Value not established.
* "VerdeMins"™ Peptide-Powered Minerals with Organic Spirulina
** Fermented Nutrient

Other Ingredients: Hypromellose, Copernicia cerifera wax.

Suggested Use: Take 3 capsules once per day.

Warning: If you are pregnant, nursing, allergic, have a medical condition, or taking any medications, consult a doctor before using this or any other dietary supplement. Do not use if inner safety seal is broken or missing. Keep out of reach of children. Store in a cool, dry place.

Select Frequency
One-time
$69.95
† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Who's it for +

Built for biohackers, athletes, and adults 30+, and anyone looking to supercharge their energy levels without the stimulant trade-off.† If you have been eyeing methylene blue, or you want a caffeine- and nicotine-free lift, this is the non-toxic, food-derived path to the same cellular benefits. Vegan capsule. No artificial fillers, colors, soy, gluten, or nuts.

Benefits +
  • Energy: Stimulant-free lift you can feel, internally generated, not borrowed.†
  • Focus: A calm, non-stimulating clarity that quiets brain fog without revving the nervous system.†
  • Longevity: Phycocyanin, NAD+ precursors, and methylated B vitamins support the mitochondria, the powerhouse of the cells.†
  • Biophotonic Capture: Chlorophyll and phycocyanin absorb a broader spectrum of light than methylene blue, without the toxicity.†
  • Antioxidant Defense: Phycocyanin activates the Nrf2 response and helps protect mitochondrial membrane potential.†
  • Peptide-Powered Minerals™: Nine essential minerals bound to spirulina peptides for intracellular delivery.†
How to use +

Three capsules once per day, ideally with breakfast. Some may notice enhanced energy and focus within hours of your first dose. Mitochondrial capacity, antioxidant defense, and methylation status build over 8 to 12 weeks of consistent use.†

CAFFEINE & NICOTINE
FREE LIFT
STIMULANT-FREE
ENERGY & FOCUS
METHYLATED.
CYANIDE-FREE B12
NON-TOXIC.
FOOD-DERIVED BLUE
VEGAN. ORGANIC.
GROWN, NOT SOURCED
THE ALTERNATIVE

A Non-Toxic, Stimulant-Free Solution
to Methylene Blue, Nicotine & Energy Drinks.

If you've heard about methylene blue, NAD+, methylated B vitamins, or peptides, this product is for you. The cellular benefits biohackers chase, without the chemical, the addiction, or the crash.

Methylene Blue
A synthetic dye, originally derived from coal tar.
Approved by the FDA only as a prescription drug for methemoglobinemia. Stains your mouth, tongue, and urine blue. Interacts dangerously with SSRIs. Not approved for sale as a dietary supplement.
Nicotine
Stimulating, but addictive and toxic.
Pouches, gums, and patches now marketed as "nootropic." The reality: a class of compounds that drive dependence and load the cardiovascular system. The wins come with a tax.
Energy Drinks
Caffeine, guarana, and sugar in a can.
A borrowed lift, paid back with a crash, jitters, and disrupted sleep. Marketed to kids and adults alike. Energy without the cellular machinery to produce it.
THE SOLUTION
MethylateBLUE™
The non-toxic, food-derived path to the same cellular benefits.†

Most people borrow energy from caffeine, sugar, or nicotine, and pay it back as a crash. MethylateBLUE™ supports the cellular machinery that actually produces energy, so the lift comes from inside the cell instead of being pulled out of tomorrow.†

Advantages:

  • Stimulant-free. No caffeine, no nicotine, no afternoon crash.†
  • Fermented nicotinamide as a direct NAD+ precursor.†
  • Methylated B-vitamins act as ATP cofactors at the mitochondria.†

Caffeine and nicotine sharpen focus by revving the nervous system, but the trade-off is anxiety, edginess, and a crash. MethylateBLUE™ supports clarity through the methylated B-vitamins your brain uses to build neurotransmitters, so focus arrives without the noise.†

Advantages:

  • Active L-5-MTHF folate and methylcobalamin B12.†
  • Cyanide-free B12 (no cyanocobalamin).†
  • Sustained, non-jittery focus — no nervous-system overload.†

Mitochondrial decline is one of the most cited mechanisms behind biological aging. MethylateBLUE™ supports mitochondrial function with phycocyanin, fermented nicotinamide, methylated B-vitamins, and peptide-bound trace minerals, the same cofactors the cell relies on every day.†

Advantages:

  • Phycocyanin helps protect mitochondrial membrane potential.†
  • Fermented nicotinamide supports NAD+ levels that decline with age.†
  • Methylation cofactors that support cellular signaling and DNA expression.†

The methylated B-vitamins inside MethylateBLUE™ are the same active forms your brain uses to build dopamine, serotonin, and norepinephrine, the neurotransmitters behind mood, drive, memory, and clarity. Active forms mean no MTHFR-style conversion bottleneck.†

Advantages:

  • L-5-MTHF and methylcobalamin support neurotransmitter synthesis.†
  • P-5-Phosphate B6 cofactor for cognitive function.†
  • Methylation in neural tissue supports clarity and mood.†

Around 40% of people carry an MTHFR variant and don't convert standard folic acid well, leaving them under-methylated even on a "complete" B-complex. MethylateBLUE™ uses the active, methylated endpoints, so the methylation cycle that drives DNA expression, detox, and signaling runs without a bottleneck.†

Advantages:

  • L-5-MTHF folate, methylcobalamin B12, R-5-Phosphate B2, P-5-Phosphate B6.†
  • Cyanide-free B12 — no cyanocobalamin.†
  • Bypasses the MTHFR conversion bottleneck.†

The immune system runs on cofactors. Zinc, selenium, and B6 are essential building blocks for immune cell function and a balanced inflammatory response, and most modern diets supply too little of them.†

Advantages:

  • Peptide-bound zinc, selenium, and copper for intracellular delivery.†
  • P-5-Phosphate B6 cofactor for immune cell function.†
  • Phycocyanin supports a balanced inflammatory response.†

Oxidative stress is a daily reality. MethylateBLUE™ supports the antioxidant enzymes your cells already make, so the system that protects you runs at full power.†

Advantages:

  • Phycocyanin helps activate the Nrf2 antioxidant response.†
  • Selenium fuels glutathione peroxidase activity.†
  • Zinc, copper, and manganese power the body's SOD enzymes.†
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THE COMPARISON

Three Capsules Cover
What Six Bottles Can't.

MethylateBLUE™ pairs a clinical dose of phycocyanin with the full methylated B-complex, fermented nicotinamide, chlorophyll, and 9 peptide-bound minerals. No other formula in this category combines all of them in a three-capsule daily serving.

CRITERIA METHYLATEBLUE™ BRAND A BRAND B BRAND C
Core Function Full Mitochondrial Stack Single B-Vitamin NAD+ Precursor Only Multi-Pill Greens
Blue Phycocyanin Extract ✓ 500 mg Organic ✓ ~100 mg
Methylated B-Complex ✓ B2 · B6 · Folate · B12 ✓ Partial (1–2 forms)
Fermented Nicotinamide (NAD+ precursor) ✓ Fermented ✓ Synthetic
Chlorophyll from Spirulina ✓ Whole-Food Source ✓
Peptide-Powered Minerals™ (9-mineral) ✓ VerdeMins™ Inorganic salts
Full Label Transparency ✓ Every Dose Listed ✓ ✓ Proprietary blend
FOUR BIOHACKER STACKS · THREE CAPSULES

Replaces What Biohackers Buy Separately.

Phycocyanin (the blue), methylated B vitamins, fermented nicotinamide, and peptide-bound minerals. The four compound families biohackers chase across four bottles, formulated into one daily dose.

What it costs to buy separately
Organic Blue Spirulina Extract (500 mg)
Phycocyanin-rich extract that activates the Nrf2 antioxidant pathway, scavenges peroxyl and hydroxyl radicals, and helps protect mitochondrial membrane potential.
$45.00
Methylated B-Complex (B2, B6, Folate, B12)
R-5-Phosphate, P-5-Phosphate, L-5-MTHF, and methylcobalamin, already in active form, bypassing MTHFR and other genetic conversion bottlenecks.
$28.00
Chlorophyll from Spirulina
Magnesium-porphyrin compound that supports electron transport, binds heavy metals, and (per Xu et al., 2014) supports mitochondrial ATP production.
$25.00
Fermented Nicotinamide (NAD+ precursor)
A direct precursor to NAD+, the coenzyme that drops with age and powers sirtuins, PARPs, and oxidative phosphorylation. Fermented for bioavailability without the flush.
$28.00
Peptide-Powered Minerals™ (9-mineral complex)
Iron, iodine, magnesium, zinc, selenium, copper, manganese, chromium, molybdenum, each bound to spirulina peptides for intracellular uptake. VerdeMins™ technology.
$38.00
Premium Trace Mineral Multi
Cofactors for mitochondrial Complexes I–IV, antioxidant enzymes (Mn-SOD, Cu/Zn-SOD, GPx), and thyroid function.
$22.00
Bought separately 6 supplements · $186+/mo
Best Solution
MethylateBLUE™ 3 capsules · $52.45/mo on subscription
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A QUICK CLARIFICATION

MethylateBLUE™ vs.
Methylene Blue (the chemical).

The names sound alike. The substances are not. Here is how they actually compare, point by point.

  METHYLATEBLUE™ METHYLENE BLUE (chemical)
Category Dietary supplement Synthetic dye / pharmaceutical
FDA status Compliant dietary ingredients Approved drug for methemoglobinemia; not approved as a supplement
What makes it blue Phycocyanin from organic spirulina A coal-tar derived thiazine dye
Mechanism Whole-cell stack: Nrf2 activation, methylation, NAD+ precursor, peptide-bound minerals Electron carrier in one narrow redox role
Breadth of action Mitochondrial, cognitive, methylation, detox, antioxidant One-sided; tightly scoped to its drug indication
Sourcing Regenerative Organic Certified® spirulina, grown on our farm Industrial chemical synthesis
Side effects Vegan capsule, no fillers, no dyes Blue-stained urine, mouth, skin; serotonin syndrome risk with SSRIs

We share the color, not the toxicity. If you want the cellular benefits the biohacker community is chasing, an integrated stack of phycocyanin, methylated B vitamins, fermented nicotinamide, and peptide-bound minerals is the non-toxic, food-derived path to that result.†

WAIT, WHY IS IT BLUE?

What Makes MethylateBLUE™ Blue?

The blue is a pigment, not a chemical.

The deep blue in every capsule is phycocyanin, the pigment-protein in spirulina that captures light and donates electrons during photosynthesis. It is not the same compound as methylene blue, the synthetic dye trending across social feeds and SNL skits. We share the color, not the toxicity.†

Virtually missing from the modern diet.

For most of human history, people ate phycocyanin indirectly through fish that fed on algae. Today, almost no one does. Concentrated organic spirulina extract is the most direct way to reintroduce it, and MethylateBLUE™ delivers a clinical 500 mg per serving.†

Broader light spectrum than methylene blue.

Chlorophyll and phycocyanin together absorb across roughly 430–662 nm, a wider biophotonic capture range than the narrower 550–670 nm absorption window of methylene blue. More of the visible spectrum entering your cells, naturally, with no synthetic dye in your bloodstream.†

THE SCIENCE

Absorption Spectra

Methylene Blue vs. Phycocyanin vs. Chlorophyll-a

Methylene Blue peaks 609, 668 nm Phycocyanin peak 620 nm Chlorophyll-a peaks 430, 662 nm
609 nm668 nm620 nm430 nm662 nm 0.00.20.40.60.81.0400450500550600650700750 WAVELENGTH (nm) ABSORBANCE

Phycocyanin and chlorophyll together absorb across a wider slice of the visible spectrum (~430–662 nm) than methylene blue (~609–668 nm). Curves are Gaussian reconstructions from published peak data (OMLC, PhotochemCAD, Zhang et al. 2018).†

A woman receiving red-light therapy with MethylateBLUE on a pedestal nearby
PAIRS WITH LIGHT

Built to Pair with
Red-Light & Sunlight.

Phycocyanin and chlorophyll are photodynamic compounds, meaning their biochemistry responds to light. When paired with red-light therapy or natural sunlight, the pigments inside every capsule can absorb a broader slice of the visible spectrum and support the same electron-donating chemistry your mitochondria run on every day.†

If you already practice red-light therapy, sauna, or grounding (walking barefoot on natural ground to absorb the earth's charge): this is the supplement that fits your lifestyle.

THE PHILOSOPHY

Ancient Pigment. Modern Biochemistry.

The Aztecs called spirulina “food of the gods.” Modern research has caught up: spirulina is rich in phycocyanin, the blue pigment that donates electrons during photosynthesis in plants. In your cells, the same chemistry helps protect mitochondria and quiet oxidative stress.†

But phycocyanin only works if the cell can use it, and that depends on B-vitamins. Most B-complexes still use folic acid and cyanocobalamin (a B12 with cyanide attached). About 40% of people carry an MTHFR variant and can't convert them, so they barely feel a thing.

MethylateBLUE™ skips the conversion. Every B is already in its active, body-ready form: L-5-MTHF folate, methylcobalamin B12 (no cyanide), and the phosphorylated forms of B2 and B6. Plus fermented nicotinamide for NAD+ (the coenzyme that powers cellular energy and drops after thirty), and nine trace minerals bound to spirulina peptides for intracellular delivery.†

The formula Sayer Ji has wanted to exist for two decades. Built around what the body actually uses, not what's cheap to put in a bottle.†

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Full Label Transparency
Third-Party Tested
FARM, NOT LAB

Made on a Farm.
Not in a Lab.

Most supplements come from a sterile industrial manufacturing laboratory. OURS COMES FROM A REGENERATIVE ORGANIC CERTIFIED® FARM.

Every bottle of MethylateBLUE™ is manufactured on a Regenerative Organic Certified® farm. A different setting, a different intent, and a different relationship to the land than the industrial supplement complex.

Seedling on our Regenerative Organic Certified farm

Peer-Reviewed Research
on Every Ingredient.

360
Studies on Spirulina
263
Systems Studied for Magnesium
75
Systems Studied for Folate

Every ingredient in MethylateBLUE™ was selected by cross-referencing GreenMedInfo™, the world's largest open-access natural health research platform. Spirulina alone is indexed across 360 peer-reviewed abstracts, magnesium across 263 health conditions, and bioactive folate across 75, and that's before counting methylcobalamin, nicotinamide, chlorophyll, and the other peptide-bound minerals in the formula. Chosen by weight of evidence, not by trend.†

R Logo THE FORMULA

Decades of Research
Behind Every Compound.

Every ingredient was chosen for a clear role inside the cell, not to pad the label. At the foundation: 500 mg of organic Blue Spirulina Extract, a phycocyanin-rich pigment-protein that helps activate the Nrf2 antioxidant pathway. Around it, the four methylated B-vitamins your mitochondria actually use, fermented nicotinamide as a NAD+ precursor, chlorophyll, and 9 peptide-bound trace minerals.†

Blue Phycocyanin Extract
THE CORNERSTONE PIGMENT

Blue Phycocyanin Extract

Phycocyanin is the deep-blue pigment-protein concentrated in organic spirulina. In photosynthesis, it captures light and donates electrons, the same chemistry researchers credit for its ability to scavenge peroxyl and hydroxyl radicals, activate the Nrf2 endogenous antioxidant response, and help protect mitochondrial membrane potential. We deliver a full 500 mg of organic blue spirulina extract per serving, a substantial dose, sourced and dried at low temperature to preserve the active chromophore.†

500 MG NRF2 ACTIVATOR ORGANIC SPIRULINA LOW-HEAT DRIED

"After cataloging thousands of studies, few compounds have impressed me like phycocyanin. It may be the best health secret you've never heard of."
Sayer Ji, Founder of GreenMedInfo™

Methylated B Vitamins
METHYLATION & SIGNALING

Methylated B Vitamins

The four active forms your cells actually use: R-5-Phosphate (B2), P-5-Phosphate (B6), L-5-MTHF (folate), and cyanide-free methylcobalamin (B12). Most B-complex products still use cyanocobalamin (B12 bound to cyanide) and synthetic folic acid. We use the bioactive endpoints, no conversion required, no cyanide.†

B2 · B6 · FOLATE · B12 METHYLATED CYANIDE-FREE B12
Fermented Nicotinamide
NAD+ PRECURSOR

Fermented Nicotinamide

The same B3 family as NMN and NR, in its fermented, food-form expression. A direct precursor to NAD+, the coenzyme that drops with age and powers sirtuins, PARPs, and the electron transport chain. The icing on the mitochondrial stack, no flush, no cyanide.†

NAD+ PRECURSOR FERMENTED NO FLUSH
Peptide-Powered Minerals
PEPTIDE-POWERED MINERALS™

Nine Minerals, Bound to Spirulina Peptides

Iron, iodine, magnesium, zinc, selenium, copper, manganese, chromium, and molybdenum. Each one fully reacted with spirulina-derived peptides (VerdeMins™), so the minerals reach the enzymes inside the cell, not just the bloodstream. No free cupric sulfate, no sodium selenite, nothing oxidizing.†

9 ESSENTIAL MINERALS PEPTIDE-BOUND VERDEMINS™
Chlorophyll from Spirulina
CLEAN ELECTRON FLOW

Chlorophyll from Spirulina

Chlorophyll partners with phycocyanin to support efficient cellular electron transport. Its metabolite enters the mitochondria and supports the chemistry that converts food into ATP. Paired with phycocyanin, the combination may also offer anti-radiation effects.†

ELECTRON TRANSPORT CELLULAR ENERGY FROM SPIRULINA
WHAT IT SUPPORTS

Energy, Focus, Longevity.
Three Daily Capsules.

Stimulant-free energy and calm focus on the surface. Underneath: mitochondria, methylation, antioxidant defense, mood, and immune balance. One stack, every major system.†

Mind & Muscle Energy
500 mg of organic blue spirulina phycocyanin paired with fermented nicotinamide and methylated B vitamins. The immediate feeling biohackers chase methylene blue for, delivered through non-toxic, food-derived inputs.†
Calm Focus
Methylated B vitamins support a steady, non-stimulating lift that quiets brain fog and anxiety without revving the nervous system.†
Brain & Cognition
L-5-MTHF and methylcobalamin support neurotransmitter synthesis (dopamine, serotonin, norepinephrine) and methylation in neural tissue.†
Mitochondrial NAD+
B2 (FAD/FMN) and fermented nicotinamide (NAD+ precursor) fuel electron transport Complexes I and II, the engine of ATP production.†
Metabolic Balance
Chromium supports insulin signaling; iodine and selenium support thyroid hormone activation and metabolic rate.†
Antioxidant Defense
Phycocyanin activates Nrf2; selenium powers glutathione peroxidase; copper, zinc, and manganese power SOD enzymes.†
Immune Balance
Zinc, selenium, and B6 are essential cofactors for immune cell function and balanced inflammatory response.†
Methylation & Detox
L-5-MTHF and methylcobalamin drive the methylation cycle; chlorophyll supports binding and clearance of metals and mycotoxins.†
Peptide-Powered Minerals™
Nine essential minerals bound to spirulina peptides for intracellular delivery, instead of inorganic oxides and sulfates.†
No Stimulant, No Crash
MethylateBLUE™ does not borrow against tomorrow's reserves the way caffeine and sugar do. It supports the cellular machinery that produces energy, so you build capacity instead of debt.†
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A glowing mitochondrion, the cellular powerhouse where MethylateBLUE supports ATP production
THE LONGEVITY CONNECTION

Mitochondria Are
the Powerhouses of Longevity.

Every "tired" you've ever felt traces back, ultimately, to mitochondria, the organelles inside almost every cell that convert food and oxygen into ATP. As we age, mitochondrial number and efficiency decline, NAD+ levels drop, and methylation slows. This is one of the most cited mechanisms behind biological aging itself. Stimulants mask it. They don't fix it.†

MethylateBLUE™ was designed to support that machinery directly: at the electron transport chain (phycocyanin, chlorophyll, the B-vitamins that act as ETC cofactors), at the methylation cycle (L-5-MTHF and cyanide-free methylcobalamin), and at the trace-mineral cofactors that every redox enzyme in the cell depends on. Three capsules a day, every major node.†

This is regenerative supplementation. Built for the long arc, not the quick lift.†

Sayer Ji
THE FORMULATOR

The Formula
He's Wanted for Decades.

Sayer Ji
Founder, GreenMedInfo™ · Author · Natural Health Researcher

"In decades of studying natural medicine, few compounds have captured my attention like phycocyanin. MethylateBLUE™ was created to pair this remarkable blue spirulina extract with precision-formulated methylation support for energy, clarity, and long-term cellular health."

Founded GreenMedInfo™: 30,000+ peer-reviewed studies curated
Published author & international speaker on natural medicine
Partnered with leading researchers who have pioneered categories and number-one-selling products
Over two decades of natural substance pharmacology research
HOW IT WORKS

Your Daily Routine, Simplified

01
TAKE 3 CAPSULES
Three capsules with breakfast. The methylated B-vitamins are best earlier in the day, they support neurotransmitter synthesis.
02
STAY CONSISTENT
Methylation status and NAD+ pools build over weeks of consistent intake. Three capsules replace a shelf of bottles, keep it simple, keep it daily.
03
FEEL THE DIFFERENCE
Some may notice enhanced energy and focus within hours of the first dose. Mitochondrial capacity, antioxidant defense, and methylation status build over 8–12 weeks.†
FREQUENTLY ASKED QUESTIONS

Everything You Need to Know

How is MethylateBLUE™ different from methylene blue, the chemical?
Different molecule. Different category. Methylene blue is a synthetic thiazine dye, FDA-approved as a prescription drug for a rare blood condition (methemoglobinemia) and not approved for sale as a dietary supplement. Its mechanism is narrow: it acts as an electron carrier in one specific redox role. MethylateBLUE™ is a dietary supplement built around phycocyanin, the blue pigment-protein in organic spirulina, paired with the methylated B vitamins, fermented nicotinamide, peptide-bound minerals, and chlorophyll your cells actually use. We share the color, not the toxicity (no blue urine, no SSRI interaction risk).†
What makes MethylateBLUE™ different from other mitochondrial or energy supplements?
Three things. First, dose: a full 500 mg of organic blue spirulina extract, most products use a fraction of that. Second, form: every B-vitamin is in its active, methylated form (R-5-Phosphate B2, P-5-Phosphate B6, L-5-MTHF folate, methylcobalamin B12) so your body doesn't have to convert anything, useful for the ~40% of people with MTHFR or related polymorphisms. Third, minerals: 9 trace minerals bound to spirulina peptides (VerdeMins™) for intracellular delivery, instead of inorganic oxides or sulfates. Every ingredient was selected by cross-referencing GreenMedInfo™'s 30,000+ peer-reviewed studies.†
Why phycocyanin, and why 500 mg?
Phycocyanin is the deep-blue chromophore in spirulina, structurally similar to bilirubin and biliverdin, two of the body's own potent antioxidants. Research has shown phycocyanin activates the Nrf2 pathway (the master switch for endogenous antioxidant defense), scavenges peroxyl and hydroxyl radicals, and helps protect mitochondrial membrane potential. We chose 500 mg per serving because that's near the higher end of doses used in clinical research, and because the protein is fragile, you need enough to deliver active material to the cell.†
Why methylated B-vitamins instead of regular B-complex?
Most B-complex products use cheap, synthetic forms: folic acid (which requires MTHFR conversion most people partially lack), and especially cyanocobalamin, a form of B12 that is literally bound to a cyanide molecule. Cyanocobalamin is so toxic that the body has to detach the cyanide before it can use the B12, and cyanocobalamin is famously what doctors administer to patients suffering from cyanide poisoning (the cyanide leaves the body bound to the B12). MethylateBLUE™ uses the bioactive, cyanide-free endpoints your cells actually use: L-5-MTHF, methylcobalamin, P-5-Phosphate, R-5-Phosphate. No conversion required. No cyanide.†
What's "fermented" nicotinamide and why does it matter?
Nicotinamide (also called niacinamide) is a direct precursor to NAD+, the coenzyme that powers Complex I of the mitochondrial electron transport chain and fuels sirtuins, PARPs, and CD38, all of which decline with age. Standard niacin causes the well-known "flush." Nicotinamide doesn't. The fermented form we use is produced through a clean microbial fermentation that increases bioavailability and avoids the residual solvents common to synthetic synthesis.†
What are Peptide-Powered Minerals™ (VerdeMins™)?
Most mineral supplements use inorganic forms (zinc oxide, magnesium oxide, ferrous sulfate) that have limited intracellular uptake. VerdeMins™ is a proprietary process that binds each mineral to small peptides naturally present in organic spirulina. Peptide-bound minerals are studied for superior intracellular bioavailability, meaning the iron, magnesium, zinc, selenium, copper, manganese, chromium, iodine, and molybdenum in MethylateBLUE™ actually reach the enzymes that need them, not just the bloodstream.†
Who formulated MethylateBLUE™?
MethylateBLUE™ was formulated by Sayer Ji, founder of GreenMedInfo™ (the world's largest open-access natural health research platform), in partnership with leading researchers and manufacturers who have pioneered new categories of bioavailable nutrition. With two decades curating 30,000+ peer-reviewed studies, Sayer built this formula based on weight of evidence, not market trends.†
Is MethylateBLUE™ vegan? Any common allergens?
Yes. MethylateBLUE™ is fully vegan. The capsule is hypromellose (plant cellulose), and the formula contains no soy, dairy, gluten, nuts, eggs, or shellfish. Other ingredients are limited to Copernicia cerifera (carnauba) wax for processing.
How should I take MethylateBLUE™?
Take 3 capsules once per day, ideally with breakfast or your first meal. The methylated B-vitamins are best taken earlier in the day because they support neurotransmitter synthesis and can feel energizing. Take consistently, methylation status and NAD+ pools build over weeks of steady intake.†
How long before I notice results?
Some may notice enhanced energy and focus within hours of the first dose. The B-vitamin and NAD+ pathways respond quickly. Mitochondrial biogenesis, antioxidant capacity, and methylation status build more gradually over 8–12 weeks of consistent use. Individual results vary with baseline status, diet, sleep, and stress load.†
Does MethylateBLUE™ use proprietary blends?
No. Full label transparency. Every ingredient, every B-vitamin, every mineral, the exact spirulina extract dose, is disclosed with its specific amount per serving on the Supplement Facts panel. You should always know exactly what you're putting in your body and how much of each compound.
Is it safe to take with medications?
Several MethylateBLUE™ ingredients can interact with medications. Methylated folate and methylcobalamin may interact with methotrexate and some chemotherapies. Iodine may interact with thyroid medications. Iron and zinc can affect absorption of antibiotics and thyroid drugs. If you are pregnant, nursing, on any prescription medication, or have a medical condition, please consult your healthcare provider before adding any new supplement.†
Will the methylated B-vitamins make me feel "wired" or anxious?
For most people, no, but a small percentage of people who are highly sensitive to methyl donors (a condition sometimes called "overmethylation") may notice subtle stimulation. If you have a history of sensitivity to methylated B-vitamins, start with a single capsule and titrate up.†
INITIAL LAUNCH · LIMITED SUPPLY

Choose Your Stack

30-Day
30-DAY SUPPLY 1 Bottle
Free Shipping
One-time + $6.95 s/h
$69.95
While Supplies Last
BEST VALUE 90-Day
90-DAY SUPPLY 3 Bottles
Free Shipping + Priority Inventory
One-time Save 6%
$65.75/btl
While Supplies Last
30-Day Money-Back Guarantee
Free Shipping Over $100
Full Label Transparency
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REGENERATE™

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